Its used in cosmetic and topical medicinal preparations. Final report on the safety assessment of myristyl myristate. It was also used as oilwatertype tacrolimus fk506 solvent. It has been attacked by scaremongers either from ignorance or more likely from a cynical desire to sell inferior products at high prices. Isopropyl myristate, present at 100 mgl, reached 94% of its chemical oxygen demand in 28 days using a municipal waste water inoculum in. Isopropyl myristate ipm has produced slight irritation of human skin, mild irritation of the rabbit eye and moderate irritation of rabbit skin. Methyl tetradecanoate, myristic acid methyl ester cas number 124107. Isopropyl myristate ipm makeup and adhesive remover. Safety data sheet northwest missouri state university. Import data and price of isopropyl myristate under hs code. Pdf isopropyl myristate production process optimization. Safety data sheet according to federal register vol. Ipm is used to dissolve lanolin and other oils, and is commonly used as a degreasant or softener in sunscreens, face creams and lipsticks.
Role of isopropyl myristate, isopropyl alcohol and a combination of both in hydrocortisone permeation across the human stratum corneum. Isopropyl myristate 110270 1 225 version 2 revision date 07112008 print date 07112008 page 4 8 requirements for storage areas and containers. Isopropyl myristate, with the chemical formula ch 3 ch 2 12 cooch ch 3 2, is an ester of myristic acid, an essential fatty acid derived from palm kernel oil and isopropyl alcohol. Viscous products, such as creams and ointments, can be difficult to filter and are normally diluted in a sterile solvent, such as isopropyl myristate ipm. Any website that suggests this material is harmful should be ignored.
Material safety data sheet section 1 isopropyl myristate 1 chemical product and company identification msds name. Isopropyl myristate ipm is the ester of isopropyl alcohol and myristic acid. Myristic acid isopropyl ester isopropyl tetradecanoate 1. Material safety data sheet duke safety office duke university. If the labelling does not mention isopropyl alcohol as a component then it will not be present. Cetearyl ethylhexanoate and isopropyl myristate shopify.
Collect and dispose of spillage as indicated in section of the sds. Isopropyl myristate is the ester of isopropyl alcohol and myristic acid. Find out more about isopropyl myristate, all the commercially available products, formulation examples and other related technical info. Sds safety data sheet isopropyl alcohol, 99% azer scientific inc 701 hemlock road morgantown pa 19543 610. Enzymatic synthesis of isopropyl myristate using immobilized lipase from bacillus cereus mtcc 8372 article pdf available in acta microbiologica et immunologica hungarica 553.
Ester of isopropyl alcohol and myristic acid vegetablederived. Pdf enzymatic synthesis of isopropyl myristate using. Eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Isopropyl myristate tetradecanoic acid, 1 methylethyl. Apr 19, 2017 isopropyl myristate is defined as a synthetic oil that is popularly used in both the cosmetics industry as well as the pharmaceutical industry. Isopropyl myristate name isopropyl myristate product identification naturalidentical flavouring substance chemical name isopropyl tetradecanoate chemical formulae c17h34o2 cas number 110270 fema number 3556 einecs number 2037514 physicochemical properties aspect colourless liquid organoleptic description. Therefore, isopropyl myristate is used as a solubilizing, spreading, and penetrat. Isopropyl myristate cas 110270 822102 emd millipore. Lastly, isopropyl myristate is also believed to have strong skin penetrating properties.
It is also used as a pesticide against head lice which works. This structure is also available as a 2d mol file or as a computed 3d sd file the 3d structure may be viewed using. Keep containers tightly closed in a dry, cool and wellventilated place. Isopropyl myristate resultz 50% topical solution class of drugs. Isopropyl myristate ipm makeup and adhesive remover stage. Isopropyl myristate safety data sheet according to federal register vol. Apr 27, 2020 isopropyl myristate msds pdf material safety data sheet. Find patient medical information for isopropyl myristate bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Gentle oilbased makeup remover which removes many types of makeup including pax prosaide and grease makeups. It is widely used as a nontoxic alternative for the control of head lice, as an emollient, and a lubricant. Isopropyl myristate is found in several everyday beauty products and is generally considered safe for consumer use.
Low viscosity fluid nongreasy emollient, tolerates wide ph range, compatible with most surfactants. Show this safety data sheet to the doctor in attendance. Composed of of isopropyl alcohol a propane derivative and myristic acid a naturallyoccurring fatty acid, isopropyl myristate is a popular cosmetic and pharmaceutical ingredient. This sds is intended to provide a brief summary of our knowledge and guidance. Isopropyl myristate is perfectly safe as a cosmetic ingredient and there are no issues with it as far as end users are concerned. Firstaid measures general advice if symptoms persist, call a physician. Isopropyl myristate, present at 100 mgl, reached 94% of its chemical oxygen demand in 28 days using a municipal waste water inoculum in the closed bottle test4. Packaging and storage preserve in tight, lightresistant containers. Isopropyl myristate consists of esters of isopropyl alcohol and saturated high molecular weight fatty acids, principally myristic acid. Isopropyl myristate msds material safety data sheet isopropyl myristate 1. Effectiveness of isopropyl myristatecyclomethicone d5. Isopropyl myristate is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products.
Its also perfect as a perfume diluent in place of other oils or alcohol. Isopropyl myristate is being studied as a skin enhancer. Long chain fatty acid esters, structurally similar to isopropyl myristate, were rapidly degraded by mixed sewage sludge1,2,3. Used as an emollient and lubricant in preshaves, aftershaves, shampoos, bath oils. Isopropyl myristate revision date 24jan2018 component casno weight % isopropyl myristate 110270 95 4. Sample recipe for isopropyl myristate making cosmetics. Tetradecanoic acid, 1methylethyl ester chemical formula.
Pediculicide widespread and common in children between the ages of 3 and 12. Isopropyl myristate can be used to dilute aroma chemicals. Identification of the substancemixture and of the companyundertaking 1. Isopropyl myristate was used as oil phase in the preparation of formulations.
Isopropyl myristate 98% isopropyl tetradecanoate sigmaaldrich. Committee to evaluate drugs ced isopropyl myristate. These products will have been purified before being used in the cosmetics to remove any residual isopropyl alcohol. Aug 30, 2019 isopropyl myristate msds pdf material safety data sheet.
Using a homogeneous reaction phase, nonspecific lipase derived from candida antartica, marketed as novozym 435, was determined to be most suitable for the enzymatic synthesis of isopropyl myristate. Isopropyl myristate is also a great, nontoxic solvent for monster clay. This is a valuable attribute, as isopropyl myristate can help other skin healing chemicals to penetrate more deeply. Isopropyl myristate finds many applications in food, cosmetic and pharmaceutical industries as an emollient, thickening agent, or lubricant. Isopropyl myristate 98% isopropyl myristate, 98% min. Steritest ez system sterility testing of products to be. The substance identifiers displayed in the infocard are the best available substance name, ec number, cas number andor the molecular and structural formulas. Role of isopropyl myristate, isopropyl alcohol and a. View detailed import data, price, monthly trends, major importing countries, major ports of isopropyl myristate under hs code 2915. Sigmaaldrich offers a number of isopropyl myristate products. Isopropyl myristate and palmitate are esters formed from isopropyl alcohol and myristic and palmitic acids. Isopropyl myristate is a synthetic oil widely used in the cos.
Can a product be alcohol free while containing isopropyl. Isopropyl myristate, the ester of myristic acid and isopropyl alcohol, is also used in topical medications. Isopropyl myristate in mumbai, maharashtra get latest price. Steritest ez system sterility testing of products to be diluted in isopropyl myristate filtration is the pharmacopoeia method of choice for sterility testing. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. Spectrum chemical nf products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. Isopropyl myristate, nf is an emollient ester of low viscosity used to reduce the greasiness of emulsions.
Despite its popularity with manufacturers, some side effects have been reported. Green synthesis of isopropyl myristate in novel single phase. Wear protective clothing as described in section 8 of this safety data sheet. In cosmetics and personal care products, isopropyl myristate functions as a binder, and skinconditioning agent a emollient. The substance identity section is calculated from substance identification information from all echa databases. Committee to evaluate drugs ced recommendations and reasons this document posted april 2010 isopropyl myristate product.
Isopropyl myristate msds pdf material safety data sheet. Isopropyl myristate msds material safety data sheet or sds, coa and coq, dossiers, brochures and other available documents. Hallstar ipmnf is a multifunctional emollient, solvent, spreading agent, penetrant synthetically produced ester of vegetal myristic acid and petrochemical isopropyl alcohol that conforms to the requirements of the national formulary monograph for isopropyl myristate. Isopropyl myristate, nf 110270 is145 spectrum chemical. Isopropyl myristate is a light, colorless, oily liquid. Chemical product and company identification product name. Isomyst, stepan d50, bisomel, ipm, tegester, crodamol i. Other local effects have included nasal and lung irritation during inhalation of aerosols in monkeys and rats, acne development after application to rabbit skin, and increased permeability of human. Mar 21, 2020 isopropyl myristate msds pdf material safety data sheet. It is generally safe, although some people with skin conditions may wish to avoid products containing.
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